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Research Interests
Synthesis and structural studies of mono- and oligosaccharide derivatives and glycoconjugates (especially amino- and iminosugars and sugar amino acids - potential glycosidase inhibitors), five- and six-membered heterocyclic compounds (especially pyrazoles, imidazoles, oxazolidines, 1,3-dioxolanes, thiazoles, pyrimidines) and hyaluronan derivatives.
Selected Publications (full list available on request)
Koóš M., Repáš M., Čiha M., Kočiš P.
Identification of 3-hydroxy-6-methyl-2H-pyran-2-one from pyrolysis of phosphoric acid-treated cellulosic materials. Carbohydr. Res. 1980, 80, 333-335. Koóš M., Steiner B., Repáš M., Sasinková V.
Preparation and characterization of some 2,5- and 2,3,5-substituted oxazolidines. Chem. Papers 1984, 38, 699-706. Koóš M., Mosher H. S.
Isopropylidenation of L-Arabinose N,N-Dimethylhydrazone. Collect. Czech. Chem. Commun. 1985, 50, 1994-1999. Koóš M., Mosher H. S.
A convenient synthesis of apiose. Carbohydr. Res. 1986, 146, 335-341. Kettmann V., Bystrický S., Sticzay T., Koóš M.
Structure of 7,14,15,17-Tetraoxa-10-azapentacyclo[10.2.1.12,11.15,8.03,9]heptadeca-3,9-dien-2-ol, a Pentacyclic Alcohol Prepared from Levoglucosenone. Acta Crystallogr. 1989, C45, 1580-1583. Koóš M., Repáš M., Steiner B., Mlynarčík D.
Preparation, characterization, and antimicrobial properties of some 1,3,5-substituted 2-pyrazolines. Chem. Papers 1990, 44, 105-110. Koóš M., Steiner B., Repáš M.
Influence of structure on antimicrobial activity of some heterocycles. I. Alkylpyrazoles and alkylisoxazoles. Chem. Papers 1991, 45, 279-286. Steiner B., Koóš M., Matulová M., Proksa B.
Synthesis of 2-Acetyl-3-methyl-4H-1,4-benzothiazine and its Derivatives. Monatsh. Chem. 1993, 124, 425-430. Koóš M., Mosher H. S.
α-Amino-α-trifluoromethyl-phenylacetonitrile: A Potential Reagent for 19F NMR Determination of Enantiomeric Purity of Acids. Tetrahedron 1993, 49, 1541-1546. Koóš M., Steiner B., Novotná Z.
Influence of Structure on Antimicrobial Activity of Some Heterocycles. IV. 1-(3-Alkylamino-2-hydroxypropyl)-2-methyl-5-nitroimidazoles. Chem. Papers 1994, 48, 54-57. Koóš M.
Synthesis and Antimicrobial Activity of Some 2-Alkyl-2H-1,4-benzothiazin-3(4H)-ones and 2-Alkylbenzo[d]imidazolo[2,1-b]thiazolidin-3-ones. Monatsh. Chem. 1994, 125, 1011-1016. Köll P., Saak W., Pohl S., Steiner B., Koóš M.
Preparation and crystal and molecular structure of 6-O-[(2S)-2,3-epoxypropyl]-1,2:3,4-di-O- isopropylidene-galactopyranose. Pyranoid ring conformation in 1,2:3,4-di-O-isopropylidene- galactopyranose and related systems. Carbohydr. Res. 1994, 265, 237-248. Koóš M.
A Versatile Route to 2,3-Unsaturated Sugar Derivatives via Corresponding 3-Acetoxy-1-Nitro-1-Alkenes. Tetrahedron Lett. 1996, 37, 415-416. Sasinková V., Koóš M.
An Alternative Synthesis of Nojirimycin and Idonojirimycin. Chem. Papers 1997, 51, 147-152. Hirsch J., Koóš M., Kováč P.
Improved synthesis of an aldobiouronic acid related to hardwood xylans, and preparation of a derivative thereof suitable for linking to proteins. Carbohydr. Res. 1998, 310, 145-149. Steiner B., Koóš M., Langer V., Gyepesová D., Smrčok Ľ.
4-Amino-4-cyano-4,6-dideoxy sugar derivatives from methyl 6-deoxy-2,3-O-isopropylidene- α-L-lyxo-hexopyranosid-4-ulose via Strecker-type reaction. Carbohydr. Res. 1998, 311, 1-9. Koóš M., Steiner B., Gajdoš J., Langer V., Gyepesová D., Smrčok Ľ., Ďurík M.
Crystal Structure of Methyl 4-acetamido-4-cyano-4,6-dideoxy-2,3-O-isopropylidene-ß-D-allopyranoside. Molecules 2000, 5, 219-226. Koóš M., Steiner B., Langer V., Gyepesová D., Ďurík M.
Preparation and structure determination of two sugar amino acids via corresponding hydantoin derivatives. Carbohydr. Res. 2000, 328, 115-126. Koóš M.
An alternative route to 2-deoxysugar and 2,3-unsaturated sugar derivatives via corresponding 1-nitro-1-alkenes. Tetrahedron Lett. 2000, 41, 5403-5406. Koóš M., Steiner B., Mičová J., Langer V., Ďurík M., Gyepesová D., Smrčok Ľ.
Crystal Structure of Methyl 4-amino-4-cyano-4,6-dideoxy-2,3-O-isopropylidene-α-L-talopyranoside. Molecules 2000, 5, 1113-1120. Koóš M., Steiner B., Mičová J., Langer V., Ďurík M., Gyepesová D.
Synthesis and structure determination of some sugar amino acids related to alanine and 6-deoxymannojirimycin. Carbohydr. Res. 2001, 332, 351-361. Mičová J., Steiner B., Koóš M., Langer V., Gyepesová D., Ďurík M., Smrčok Ľ.
Some amino sugars structurally related to 6-deoxymannojirimycin precursors prepared from methyl 6-deoxy-2,3-O-isopropylidene-α-D-lyxo-hexofuranosid-5-ulose and methyl 2,3-O-isopropylidene-α-D-lyxo- pentodialdo-1,4-furanoside. Carbohydr. Res. 2002, 337, 663-672. Mičová J., Steiner B., Koóš M., Gajdoš J., Langer V., Gyepesová D.
Synthesis, Crystal Structure, and Conformation of Methyl 5-O-acetyl-5-cyano-6-deoxy- 2,3-O-isopropylidene-ß-L-gulofuranoside. Molecules 2002, 7, 437-446. Koóš M., Mičová J., Steiner B., Alföldi J.
An efficient and versatile synthesis of apiose and some C-1-aldehyde- and/or 2,3-O-protected derivatives. Tetrahedron Lett. 2002, 43, 5405-5406. Mičová J., Steiner B., Koóš M., Langer V., Gyepesová D.
Synthesis of 4-Carbamoyl-2-oxazolidinones C-4-Linked with a Saccharide Moiety via Bucherer-Bergs Reaction of Hexofuranos-5-uloses. Synlett 2002, 1715-1717. Steiner B., Mičová J., Koóš M., Langer V., Gyepesová D.
Some non-anomerically C-C-linked carbohydrate amino acids related to leucine - synthesis and structure determination. Carbohydr. Res. 2003, 338, 1349-1357. Mičová J., Steiner B., Koóš M., Langer V., Gyepesová D.
Characterisation and X-ray crystallography of products from the Bucherer-Bergs reaction of methyl 2,3-O-isopropylidene-α-D-lyxo-pentodialdo-1,4-furanoside. Carbohydr. Res. 2003, 338, 1917-1924. Mičová J., Steiner B., Koóš M., Langer V., Gyepesová D.
Synthesis and structure determination of some nonanomerically C-C-linked serine glycoconjugates structurally related to mannojirimycin. Carbohydr. Res. 2004, 339, 2187-2195. Hirsch J., Langer V., Koóš M.
Synthesis and Molecular Structure of Methyl 4-O-methyl-α-D-glucopyranuronate. Molecules 2005, 10, 251-258. Langer V., Steiner B., Mičová J., Koóš M.
6-O-Cyanomethyl-1,2:3,4-di-O-isopropylidene-α-D-galactopyranose. Acta Crystallogr., Sect. E 2005, E61, o779-o781. Hirsch J., Koóš M.
Simple Synthesis of Methyl 2-O-ß-D-Xylopyranosyl-α-L-arabinofuranoside, a Fragment of Natural Arabinoglucuronoxylans. Chem. Papers 2005, 59, 21-24. Langer V., Mičová J., Steiner B., Koóš M.
3-O-Benzoyl-1,2-O-isopropylidene-ß-D-fructopyranose. Acta Crystallogr., Sect. E 2005, E61, o2172-o2174. Langer V., Koóš M., Gyepesová D., Sládkovičová M., Lustoň J., Kronek J.
Three isomeric forms of hydroxyphenyl-2-oxazoline: 2-(2-hydroxyphenyl)-2-oxazoline, 2-(3-hydroxyphenyl)- 2-oxazoline and 2-(4-hydroxyphenyl)-2-oxazoline. Acta Crystallogr., Sect. C 2005, C61, o602-o606. Mlčochová P., Bystrický S., Steiner B., Machová E., Koóš M., Velebný V.,
Krčmář M.
Synthesis and characterization of new biodegradable hyaluronan alkyl derivatives. Biopolymers 2006, 81, 74-79. Langer V., Gyepesová D., Scholzová E., Lustoň J., Kronek J., Koóš M.
2-(4-Hydroxyphenyl)-4,4-dimethyl-2-oxazoline: X-ray and DFT study. Acta Crystallogr., Sect. C 2006, C62, o416-o418. Langer V., Mičová J., Steiner B., Koóš M.
2-(Benzimidazol-2-ylsulfanyl)butanoic acid. Acta Crystallogr., Sect. E 2006, E62, o2138-o2140. Smrčok Ľ., Sládkovičová M., Langer V., Wilson C.C., Koóš M.
On hydrogen bonding in 1,6-anhydro-ß-D-glucopyranose (levoglucosan): X-ray and neutron diffraction and DFT study. Acta Crystallogr., Sect. B 2006, B62, 912-918. Langer V.; Scholtzová E.; Koóš M.
1-Phenyl-3-(4-bromophenyl)-5-(4-dimethylaminophenyl)-2-pyrazoline: X-ray and DFT studies. Acta Crystallogr., Sect. C 2007, C63, o340-o342. Mlčochová P.; Hájková V.; Steiner B.; Bystrický S.; Koóš M.; Medová M.; Velebný V.
Preparation and characterization of biodegradable alkylether derivatives of hyaluronan. Carbohydr. Polym. 2007, 69, 344-352. Hýrošová E.; Fišera Ľ.; Jame R.M.-A.; Prónayová N.; Medvecký M.; Koóš M.
Diastereoselective synthesis of some carbocyclic 2'-oxa-3'-aza-nucleosides. Chemistry of Heterocyclic Compounds 2007, 43, 10-17. Kolarovič A.; Fišera Ľ.; Toma Š.; Prónayová N.; Koóš M.
1,3-Dipolar cycloaddition of nitrones with alkenes in ionic liquids. Polish J. Chem. 2007, 81, 1963-1970. Rehák J.; Fišera Ľ.; Kožíšek J.; Perašínová L.; Steiner B.; Koóš M.
Samarium diiodide-induced reductive coupling of chiral nitrones with methyl acrylate. ARKIVOC 2008, part (viii), 18-27. Hýrošová E.; Fišera Ľ.; Medvecký M.; Reissig H.-U.; Al-Harrasi A.; Koóš M.
From sugars to modified nucleosides. ARKIVOC 2009, part (ix), 122-142. Langer V.; Steiner B.; Koóš M.
2,3:4,6-Di-O-isopropylidene-α-L-sorbofuranose and 2,3-O-isopropylidene-α-L-sorbofuranose. Acta Crystallogr., Sect. C 2009, C65, o151-o154. Hirsch J.; Koóš M.; Tvaroška I.
Synthesis of saccharide precursors for preparation of potential inhibitors of glycosyltransferases. Chem. Papers 2009, 63, 329-335. Steiner B.; Langer V.; Koóš M.
Synthesis and X-ray structure of a C5-C4-linked glucofuranose-oxazolidin-2-one. Carbohydr. Res. 2009, 344, 2079-2082. Hirsch J.; Koóš M.; Kováč P.
Chemical synthesis of oligosaccharides related to plant xylans. In N.E. Nifantiev (Ed.). Progress in the synthesis of complex carbohydrate chains of plant and microbial polysaccharides. Trivandrum: Transworld Research Network, 2009. ISBN 978-81-7895-424-0. Chapter 2.3., p. 61-92. |